The Upstate is the region in the westernmost part of South Carolina, United States, also known as the Upcountry, which is the historical term. Although loosely defined among locals, the general definition includes the 10 counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville–Spartanburg–Anderson, SC combined statistical area, as first defined by the Office of Management and Budget (OMB) in 2015. In 2018, the OMB redefined the CSA such that it no longer included Abbeville County. That definition remains as of 2020.

The region's population was 1,347,112 as of 2016. Situated between Atlanta and Charlotte, the Upstate is the geographical center of the Charlanta megaregion. After BMW's initial investment, foreign companies, including others from Germany, have a substantial presence in the Upstate; several large corporations have established regional, national, or continental headquarters in the area. Greenville is the largest city in the region with a population of 72,227 and an urban-area population of 400,492, and it is the base of most commercial activity. Spartanburg and Anderson are next in population.